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Chunk #26 — DISCUSSION

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Resiliency in adolescents at high risk for substance abuse: flexible adaptation via subthalamic nucleus and linkage to drinking and drug use in early adulthood.
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The novel finding reported is a neural link shared between resiliency and working memory. Negative relationships were found between resiliency and activity in the interconnected basal ganglia structures, the STN and pallidum, during working memory. Likely because of their size and partial volume averaging with surrounding white matter, these nuclei were not detected in first level task analyses, but were prominently localized in subsequent correlational analyses.