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Chunk #27 — DISCUSSION

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Resiliency in adolescents at high risk for substance abuse: flexible adaptation via subthalamic nucleus and linkage to drinking and drug use in early adulthood.
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Investigation of task-related functional connectivity found Low and High resiliency groups differed in connectivity strength between the STN and median cingulate. The Low resiliency group had significantly more substance use, earlier onset of drinking, and more alcohol problems than the High group, as expected. However, these use and vulnerability measures were not related to connectivity; therefore it is unclear whether this functional coupling represents a pathway linking resiliency, working memory and substance use as predicted.