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Chunk #6 — Methods and Materials — Neuroimaging Methods — fMRI Processing

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General and specific functional connectivity disturbances in first-episode schizophrenia during cognitive control performance.
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each participant’s brain into discrete regions of interest to represent network nodes (19,38,39) using an anatomic atlas (40). Regions with less than 25% brain coverage were excluded, yielding 78 anatomic regions (Table S1 in Supplement 1). Pairwise Pearson correlations between regional mean beta series were computed to generate a {78 × 78} functional connectivity matrix for each participant and each task condition (A or B cue). These correlations between regional beta series reflected correlated variations in hemo-dynamic responses evoked by each task condition. An overview of our method is provided in Figure 1 (see Section S1 in Supplement 1 for further details).