SNPs with association p-values < 0.01 (n=3,521) were then examined for enrichment of eQTLs and mQTLs. Significant enrichment was observed for frontal eQTLs (p=0.001) as well as for cerebellar eQTLs (p=0.033) and parietal eQTLs (p=0.003) (Figure 4a-c). Furthermore, enrichment of cerebellar mQTLs was observed (p<0.001) with an enrichment p-value of p<0.001 (Figure 4d), suggesting that these SNPs are more likely to influence the methylation state than expected by chance. No significant enrichment for either genic (p=0.54) or missense variants (0.34) was observed. A similar analysis examining only the top SNPs with association p-values <0.001 (n=415) demonstrated no significant enrichment for mQTLs or for eQTLs (p>0.05).
