After correction for multiple hypothesis testing, there was no evidence for enrichment of specific miRNA binding sites among the LD-blocks containing top SNPs compared to the genes matched by size and marker density (see Supplementary Table S5). The strongest enrichment was found in 49 high-confidence (TargetScan probability>0.9) predicted miRNA-219-5p/508/508-3p/4782-3p targets, two of which have at least one SNP with p<0.001 (empirical p=0.011, corrected p=0.060) in the case-control GWAS result. A similar level of enrichment was also found in 89 high-confidence predicted miR-130ac/301ab/301b/301b-3p/454/721/4295/3666 targets, two of which have at least one SNP with p<0.001 in the trio TDT result. In the pathway analyses, no results achieved significance at the corrected p-value (lowest corrected p=0.55) (see Supplementary Table S6).
