All qPCR data represent at least three independent biological experiments. Data were analyzed using GraphPad Prism 6 software. Values are expressed as means ± SEM. Statistical significance was tested using one-way ANOVA with Tukey's post hoc test for comparison of all sample means. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.