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Chunk #38 — 4. Discussion

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A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models.
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righting reflex, in humans a self-report measure of the number of drinks needed to achieve a subjective “effect” the first five times an individual drank alcohol is often used (Schuckit et al., 2001). Such differences in phenotype definitions may contribute to discrepancies between the human and animal literatures. With this in mind a concerted effort for both animal and human researchers to adopt alcohol related measures that may be more reliably collected in both species may provide more usable data for meaningful comparisons.