Finally, we return to the original goal of this analysis. Here, we entertained the possibility that the path to greater phenotypic consilience might be illuminated by searching for consilience in QTL mapping of chromosomal regions. The strength of the correspondence seen in the two cases that are elucidated here suggests that syntenic mapping will continue to be a valuable exercise. This has the potential to be one of the fastest paths to the underlying genes currently available, and that additional examples of conserved genetic signal will be discovered as the fidelity of both human and mouse maps continues to improve. This task may be enhanced by the use of similar maps between studies and by author's providing accurate confidence intervals. . Human linkage studies are can suffer from lack of power, which can make replication of a linkage finding very challenging (see Sham et al., 2002). Another option would be to consider cases where an initial linkage signal has been followed up with fine-mapping that resulted in the identification of associated genetic variants, which have been confidently confirmed in subsequent
