health behavioral environment (39). In adulthood, the experience of traumatic events and neighborhood social cohesion interacted with aggregated genetic risk to influence the number of cigarettes smoked per day. The interaction between the experience of traumatic events and neighborhood social cohesion and aggregated genetic risk seemed to be largely driven by a single variant (rs203652) located on the CHRNA5-CHRNA3-CHRNB4 gene cluster (98). Parental monitoring also interacted with genetic variant, rs16919968, to determine nicotine dependence in adulthood (33), while treatment status interacted with genetic risk for smoking cessation (34).
