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Chunk #19 — Results — Replication study

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Interaction between SLC6A4 promoter variants and childhood trauma on the age at onset of bipolar disorders.
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Multivariate regression analyses used transformed AAO (sqrt(AAO)) that fulfilled the normality assumption (Shapiro-Wilk W = 0.98; p > 0.05). No significant result was observed when studying physical neglect, physical abuse, nor sexual abuse. We found an interaction between emotional abuse and ‘LS’ genotype on the AAO (p = 0.02) and a trend for an interaction between emotional neglect and ‘LS’ genotype on the AAO (p = 0.08). No interaction was found with ‘SS’ genotype in both models (see Tables 3 and 4).