and Oslo cohorts (one-tailed p-value = 0.047, OR for the minor allele = 0.85, 95% CI = 0.71–1.02). We replicated directionality of effect for the A allele of rs393152 within the CHARGE cohort (one-tailed p-value = 0.318, OR for the minor allele = 0.97, 95% CI = 0.85–1.10). We conducted an inverse variance weighted meta-analysis 18 and found a two-tailed meta-analysis p-value of 1.65 × 10−7 (meta analysis OR = 0.91, 95% CI = 0.88–0.94) (Figure 1).
