We found 8 SNPs on 4 chromosomes that were genome-wide significant in PD, thus requiring a Bonferroni corrected p-value significance threshold of 0.00625 (Table 2). Across all 8 SNPs, we found that the A allele of rs393152, within the CRHR1 region on chromosome 17 (within the extended MAPT locus) and with a minor allele frequency of 23.1%, significantly increased AD risk in the ADGC cohort (p-value = 1.17 × 10−4, odds ratio (OR) for the minor allele = 0.90, 95% confidence interval (CI) = 0.86–0.95) (Table 2) (Figure 1). In a replication analysis, we found that the A allele of rs393152 also significantly increased AD risk within the GERAD (one-tailed p-value = 0.0048, OR for the minor allele = 0.92, 95% CI = 0.86–0.98), deCODE (one-tailed p-value = 0.017, OR for the minor allele = 0.92, 95% CI = 0.85–0.99) and Oslo cohorts (one-tailed p-value = 0.047, OR for the minor allele = 0.85, 95% CI = 0.71–1.02). We replicated directionality of effect for the A allele of rs393152 within the CHARGE cohort (one-tailed p-value = 0.318, OR for the
