Next, we assessed differential transcriptomic and proteomic regulation of TUD risk loci in the dorsolateral prefrontal cortex (DLPFC) by performing TWAS (mRNA and splicing) and PWAS, respectively. Associations across these three regulatory models identified 50 unique TUD risk genes (32, mRNA expression; 13, splicing expression; 14, proteome expression; Supplementary Tables 19 and 20). Colocalization analysis identified four genes and proteins (NT5C2, GPX1, ABHD12, RHCE) associated with TUD via their regulation of brain expression levels and protein abundance (PP4 >0.80, Supplementary Table 21, Supplementary Figure 7).
