Significant enrichments were also observed in presynaptic vesicle and nuclear gene sets, but not after conditioning on the PSD (Pmin=0.66), whereas the PSD gene set remained significantly enriched for hits after conditioning on the other sets individually (Pmax=5.20 × 10−3) or combined (P=0.016) (Supplementary Section 13). The most parsimonious interpretation is that our findings specifically implicate the PSD, although we cannot exclude the possibility of effects across multiple functional sets.