To explore our findings in the context of a less restricted set of classifications, we performed enrichment analyses using the GO annotation. Of all categories, ‘the synapse' (GO: 45202) was by two orders of magnitude the most significantly enriched (P=9.6 × 10−9) (Supplementary Section 11 and Supplementary Table S4) but most of this signal was attributable to the PSD gene set (P=0.049 after removing PSD genes, Supplementary Table S5). Only one subcategory of ‘the synapse' GO: 45202 was enriched after PSD genes were removed: GO: 30672 ‘synaptic vesicle membrane' (P=0.036, Supplementary Table S5).
