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Chunk #35 — Childhood and Developmental Disorders

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The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies.
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CSD measures have the potential to be applied to childhood disorders, as they provide enhanced spatial resolution, sensitivity to the regional brain electrical activity, and reference independence to the raw EEG potentials (Perrin et al., 1987a; Srinivasan et al., 1998a). Although few in number, studies have reported CSD activation profiles in conduct disorder (CD), autism spectrum disorders (ASD), and attention deficit hyperactivity disorder (ADHD). Bauer and Hesselbrock (2001) examined the performance of individuals with CD in a memory scanning task and found that P3 related CSD activations for matching minus non-matching trials were markedly weaker over the left frontal region in individuals with CD symptoms compared to those without these symptoms. Milne (2011) studied early ERP components during the presentation of visual stimuli (Gabor patches) and found that high functioning adolescents with ASD showed lower P1 related CSD activation as well as decreased alpha phase coherence compared to controls. Duffy and Als (2012) employed CSD transformed spectral coherence of the resting EEG in 463 children with ASD and 571 neuro-typical controls in order to see the classification accuracy based on