We performed a GWAS on 381 participants for ten phenotypes at 5,476,100 SNPs; results are shown in Table S4. Across the 10 factors we identified associations whose significance approached or exceeded 5×10−8, which is often used as the threshold for genome-wide significance. No single test produced a P-value low enough for us to consider it incontrovertible. Nonetheless, the two most significant associations (one with a baseline factor, and one with a response factor) involved genes that, on the basis of prior biological evidence, are good candidates for being associated with these phenotypes. We view these results as generating credible hypotheses that can be evaluated in future studies.
