We identified a potential association between rs3784943 and factor F1, which we labeled “10 mg response” (P = 4.58×10−8; log10BF = 5.26). The frequency of this SNP did not show marked differences among populations in 1000 Genomes, and an analysis of the Caucasian-only subset yielded consistent results (P = 6.22×10−7; log10BF = 3.53). The factor loadings show that this factor consists primarily of responses in participants in the 10 mg session. Friendliness, Elation, Vigor, Feel, High, More, Like, Amphetamine, Benzedrine, Marijuana and MBG have positive loadings on this factor, while Depression, Fatigue, Confusion and PCAG have negative loadings (Figure 2A). Examination of the mean values of the raw phenotypic data for individuals in the upper and lower deciles of this factor show that, although the 20 mg session values did not contribute to the factor through the loadings, there is substantial correlation with a positive response to 20 mg (Figure 2B). Rs3784943 falls within the 8th intron of the gene cadherin 13 (CDH13) which codes for a cell adhesion molecule that is highly expressed in the brain [50]. The minor
