manifest significantly less evoked delta and theta ERO power than age-matched controls (Jones et al., 2006a). Rangaswamy et al. (2007) have shown that adolescent offspring of ethanol dependent individuals have reduced delta and theta ERO power. These results suggest that a decrease in delta and theta EROs may antecede the development of ethanol dependence. Evidence from the COGA project has also shown a significant linkage and association between parietal delta ERO power and the cholinergic muscarinic receptor gene (CHRM2) on chromosome 7 (Jones et al., 2004, 2006b). These findings have provided a better understanding of the neurophysiological mechanisms and genes contributing to the human P3 component (for reviews, see Begleiter and Porjesz, 2006; Porjesz et al., 2005; Rangaswamy and Porjesz, 2008).
