In the present study, we used miRNA arrays to identify miRNAs with altered expression in the frontal cortex of 14 alcoholics and 13 age- and sex-matched controls that were used in our microarray studies (Liu et al., 2006).Since miRNAs are known to act in part as modulators of gene expression, we correlated mRNA and miRNA profiles across the entire genome to determine whether differentially expressed miRNAs could be influencing the mRNA expression changes observed in the frontal cortex of alcoholics. The predicted mRNA targets for each differentially expressed miRNA were determined and compared with the list of differentially expressed mRNAs reported in Liu et al (Liu et al., 2006)from the same samples.
