Perceived sibling problem substance use (problem alcohol and/or illicit drug use) was more common among offspring ever smokers (OR=1.45; 95%CI:1.10–1.94) and regular smokers (OR=2.04; 95%CI:1.41–2.95) and among offspring with ND (OR=1.75; 95%CI:1.19–2.57) as compared to offspring never smokers.