GO-CAM is a strict semantic, descriptive and computable model that enables curators to link together standard GO annotations and enrich them with biological context. In addition, GO-CAMs allow curators to link molecular activities (instances of GO molecular function terms) through causal relationships to describe larger biological programs (Figure 1). We continue to develop Noctua, the new GO curation platform (see GO toolset), to support the curation and review of both standard and GO-CAM annotations. The GO-CAM documentation, data and download are directly accessible through http://geneontology.org/go-cam. As GO-CAMs link standard GO annotations, those GO annotations can be integrated into the GO annotation files used in traditional GO-based analyses like statistical GO enrichment testing.
