Considering the extensive comorbidity between major depression and PTSD82, we conducted conditional analysis with Multi-trait Conditional and Joint Analysis (mtCOJO)30 using GCTA software with the MVP PCL-total symptom severity summary statistics as the primary analysis and the PGC MDD2 (excluding 23andMe due to data unavailability)83 summary statistics to condition the analysis for depression. Additional summary statistics for autism spectrum disorder, anorexia nervosa, anxiety (case-control), alcohol dependence, schizophrenia, bipolar disorder, and attention deficit hyperactivity disorder were obtained from https://www.med.unc.edu/pgc/results-and-downloads/.
