When considering the MEBS Binge Eating subscale, there were significant main effects for both dietary restraint (p's < .001) and impulsivity (p's < .03) in most all models. Notably, however, regression coefficients were not significant for the main effects of 5-HT2a or 5-HTTLPR risk alleles. In addition, the 2-way interactions between genotype and dietary restraint, genotype and impulsivity, as well as the 3-way interactions of genotype by dietary restraint by impulsivity interactions, were not significant for MEBS Binge Eating. Importantly, we examined whether controlling for BMI in analyses would result in any significant interactive associations. This was done given associations between BMI, dietary restraint, and binge eating (Fitzgibbon et al., 1998; Stewart, 2002) as well as previous research linking both 5-HT risk genes to body weight regulation (Aubert et al., 2000; Fumeron et al., 2001). However, results remained unchanged when BMI was entered in the first step of the regression models (data not shown), suggesting BMI does not play a role in interactive associations.
