The possible influence of impulsivity and dietary restraint on associations between serotonin genes and binge eating.
paper
Cited
Public
- Authors
- Racine, Sarah E; Culbert, Kristen M; Larson, Christine L; Klump, Kelly L
- Year
- 2009
- Journal
- Journal of psychiatric research
- PMID
- 19493540
- DOI
- 10.1016/j.jpsychires.2009.05.002
- PMCID
- PMC2870529
Although serotonin (5-HT) genes are thought to be involved in the etiology of bulimia nervosa and binge eating, findings from molecular genetic studies are inconclusive. This may be due to limitations of past research, such as a failure to consider the influence of quantitative traits and gene-environment interactions. The current study investigated these issues by examining whether quantitative traits (i.e., impulsivity) and environmental exposure factors (i.e., dietary restraint) moderate 5-HT gene/binge eating associations in a sample of young women (N = 344). Binge eating was assessed using the Minnesota Eating Behavior Survey and the Dutch Eating Behavior Questionnaire (DEBQ). Impulsivity was assessed with the Barratt Impulsiveness Scale-Version 11. Dietary restraint was measured with a factor score derived from common restraint scales. Saliva samples were genotyped for the 5-HT2a receptor T102C polymorphism and 5-HT transporter promoter polymorphism. As expected, impulsivity and dietary restraint were associated with binge eating. Although the T allele of the 5-HT2a receptor gene and the s allele of the 5-HTT gene were associated with higher levels of impulsivity, there were no main effects of 5-HT genotypes on any binge eating measure, and interactions between genotypes, impulsivity, and dietary restraint were non-significant. In conclusion, we found no evidence to suggest that dietary restraint or impulsivity moderate associations between binge eating and these 5-HT genes. Future research should continue to explore interaction effects by examining larger samples, assessing dietary intake directly, and investigating other genes, traits, and environmental factors that may be related to binge eating and bulimia nervosa.
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| Name | Type |
|---|---|
| -1438G/A local | variant |
| -1438G/A A allele local | variant |
| -1438G/A G allele local | variant |
| 5-HT2a receptor T102C genotype local | variant |
| 5-HT genes local | gene |
| 5-HTT | gene |
| 5-HTTLPR | variant |
| allele | cohort |
| Ballet dancing local | phenotype |
| Barratt Impulsiveness Scale, Version 11 local | drug |
| Bdnf | gene |
| binge eating | phenotype |
| BIS-11 Total Score local | phenotype |
| BMI | phenotype |
| body dissatisfaction | phenotype |
| body mass index | phenotype |
| borderline personality disorder | phenotype |
| bulimia nervosa | phenotype |
| Bulimia nervosa symptoms local | phenotype |
| bulimic behaviors local | phenotype |
| bulimic phenotypes local | phenotype |
| caloric restriction | phenotype |
| Caucasian females local | cohort |
| DEBQ Emotional Eating scale local | phenotype |
| DEBQ Emotional Eating subscale local | drug |
| DEBQ Emotional Eating subscale local | phenotype |
| DEBQ Restrained Eating Scale (DRES) local | phenotype |
| DEBQ restraint scale local | phenotype |
| dietary restraint local | phenotype |
| Dietary restraint local | phenotype |
| Dietary Restraint local | phenotype |
| dietary restraint factor local | phenotype |
| dNTPs | drug |
| dopamine genes local | gene |
| Dutch Eating Behavior Questionnaire local | drug |
| Dutch Eating Behavior Questionnaire local | phenotype |
| eating disorder | phenotype |
| Eating Disorder Examination local | phenotype |
| Eating Disorder Examination-Questionnaire local | phenotype |
| eating disorders | phenotype |
| Eating disorder syndromes local | phenotype |
| EDE-Q restraint scale local | phenotype |
| emotional eating | phenotype |
| general psychiatric patients local | cohort |
| genetic variants | cohort |
| genotype/allele variables local | variant |
| harm avoidance | phenotype |
| Htr2a | gene |
| HTR2A T102C local | variant |
| HTR2C | gene |
| impulsivity | phenotype |
| intent to diet local | phenotype |
| Interview methods local | drug |
| MEBS Binge Eating subscale local | drug |
| MEBS Total Score local | phenotype |
| MgCl2 | drug |
| Minnesota Eating Behavior Survey local | drug |
| Non-clinical population local | cohort |
| Non-planning impulsivity | phenotype |
| novelty seeking | phenotype |
| obesity | phenotype |
| Obsessive-compulsive traits | phenotype |
| Oragene DNA Self-Collection kit local | drug |
| parental criticism | phenotype |
| participants | cohort |
| personality traits | phenotype |
| prison inmates | cohort |
| restrained eating local | phenotype |
| Restraint subscale local | phenotype |
| risk allele | cohort |
| saliva | drug |
| Self-report measures local | drug |
| SLC6A4 | gene |
| SLC6A4 5-HTTLPR local | variant |
| substance abuse patients local | cohort |
| T102C local | variant |
| T102C C allele local | variant |
| T102C T allele local | variant |
| Taq Polymerase local | drug |
| undergraduate students local | cohort |
| urgency | phenotype |
| Weight-based teasing local | phenotype |
| Weight Preoccupation local | phenotype |
| women | cohort |
| young adult women local | cohort |
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