to reduce ethanol intake in mice (Blednov et al., 2015). Isoquercitrin, which is found in medicinal herbs like St. John’s Wort, appears to increase the expression of many genes in the cholesterol pathway (Soundararajan et al., 2008) that were decreased by ethanol exposure (Table 4). Taurine, which is found in many energy drinks, is a glycine receptor agonist. The FDA has warned that mixing of those energy drinks with alcohol should be avoided because it is associated with higher levels of alcohol consumption, especially in adolescents and young adults (Food and Drug Administration, 2010); this might be in part because it reduces the negative effects of alcohol. The upstream regulator analysis also indicates that norepinephrine is active; two drugs that block α1 adrenergic receptors, prazosin and doxazosin, are in randomized trials for alcohol dependence and alcohol dependence plus PTSD (Kenna et al., 2015; Simpson et al., 2015). The positive score for morphine (Table 5) indicates that an opioid antagaonist like Naltrexone may be effective in countering some of the effects of the excessive drinking.
