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Chunk #34 — Results — Including the SNP score in the Model

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The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption.
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Also listed in Table 2 is the SNP score relationship with frequency of alcohol use in the subsample of current alcohol users. As is clear from the table, the SNP score was unrelated to frequency of alcohol use at ages 14, 17, and 20. It was, however, significantly associated at age 24, but in the opposite direction as that observed for nicotine use. That is, at age 24 higher SNP scores were associated with greater CPD in smokers but less frequent drinking in drinkers. The SNP score also showed no association with alcohol use in the full sample or subsample of smokers (results not shown).