controls with the Val/Val genotype report a decreased ability to experience reward in the routine of daily life and report less happiness compared with those with the Met/Met genotype (20). In a recent functional fMRI study healthy controls with the Val/Val genotype had greater activation of amygdala in response to fearful/angry facial stimuli (53). Our findings extend these studies further by demonstrating that COMT Val158Met variation may also moderate subjective drug responses to nicotine.
