COMT Val158Met modulates subjective responses to intravenous nicotine and cognitive performance in abstinent smokers.

paper Cited Public

Authors: Herman, A I; Jatlow, P I; Gelernter, J; Listman, J B; Sofuoglu, M
Year: 2013
Journal: The pharmacogenomics journal
PMID: 23459442
DOI: 10.1038/tpj.2013.1
PMCID: PMC3675163

#	Section	Preview
0	Introduction	Catechol-O-methyltransferase (COMT) is an enzyme that inactivates dopamine (DA), epinephrine, and…
1	Introduction	A recent meta-analysis concluded that the Val/Val genotype may be a risk factor for developing…
2	Introduction	The goal of this study was to determine the influence of the COMT Val158Met polymorphism on nicotine…
3	Materials and methods — Subjects	We recruited 124 non-treatment-seeking cigarette smokers in and around New Haven, Connecticut…
4	Materials and methods — Subjects	The participants were medically healthy and did not have current active medical problems (including…
5	Materials and methods — Procedure	Following an overnight abstinence from smoking, the participants arrived at the outpatient clinic at…
6	Materials and methods — Nicotine Administration	Nicotine bitartrate was acquired from Interchem Corporation (Manchester, Connecticut). A research…
7	Materials and methods — Dependent Measures	Outcome measures assessed biochemical, physiological, subjective, and cognitive domains. Biochemical…
8	Materials and methods — Dependent Measures	The subjective measures included the Drug Effects Questionnaire (DEQ), the Brief Questionnaire on…
9	Materials and methods — Dependent Measures	reflecting nicotine deprivation levels (37, 38). The MNWS measures withdrawal symptoms from tobacco…
10	Materials and methods — Dependent Measures	Cognitive testing was measured using the Mathematical Processing (MP) task, the Running Memory…
11	Materials and methods — Dependent Measures	The MP assessed basic computational skills. This task displays arithmetic problems involving three…
12	Materials and methods — Dependent Measures	The CPT measured attention, concentration, and working memory. This task involves single characters…
13	Materials and methods — Dependent Measures	The Stroop test assessed attention/concentration, shifting perceptual sets, and the suppression of a…
14	Materials and methods — Dependent Measures — Assays	Nicotine, cotinine and trans-3'-hydroxycotinine (3HC)/cotinine ratios were determined by tandem mass…
15	Materials and methods — Genotyping	DNA was extracted from peripheral blood using a commercial kit (PureGene™; Gentra, Minneapolis,…
16	Materials and methods — Data Analysis	Study outcomes were analyzed with a repeated-measures model using the Statistical Analysis System…
17	Materials and methods — Data Analysis	50). For the NWSC, BQSU, PANAS, and cognitive measures, the assessments were completed at the…
18	Materials and methods — Data Analysis	Subjects were classified as genetically AA or EA on the basis of the AIMs panel, using the program…
19	Results — Physiological	The systolic blood pressure, diastolic blood pressure, and heart rate responses were dose-dependent…

Name	Type
0.5 mg nicotine local	drug
1.0 mg nicotine local	drug
3HC/cotinine ratio local	drug
3-hydroxycotinine	drug
AA group	cohort
AA smokers local	cohort
Ability to experience reward local	phenotype
abstinence	phenotype
addiction	phenotype
African American	cohort
alcohol	phenotype
amygdala	anatomy
amygdala activation local	phenotype
anxiety	phenotype
attention	phenotype
Automated Neuropsychological Assessment Metrics (ANAM) local	phenotype
aversive responses to nicotine local	phenotype
Aversive stimuli local	phenotype
baseline nicotine exposure local	phenotype
basic computational skills local	phenotype
blood pressure	phenotype
BMI	phenotype
body mass index	phenotype
BQSU local	phenotype
brain areas associated with cigarette craving local	anatomy
Brief Questionnaire on Smoking Urges local	phenotype
caffeine	drug
Caffeine withdrawal local	phenotype
carbon monoxide	drug
cardiovascular responses local	phenotype
cigarette craving local	phenotype
cigarettes	phenotype
CO	drug
cognition	phenotype
Cognitive assessments local	phenotype
cognitive efficiency	phenotype
cognitive flexibility	phenotype
cognitive measures	phenotype
Cognitive stability local	phenotype
COMT	gene
COMT Met carriers local	variant
COMT rs4680 local	variant
COMT Val158Met	gene
COMT Val158Met Met local	variant
COMT Val158Met Met allele local	variant
COMT Val158Met Met carriers local	variant
COMT Val158Met (Val/Val) local	variant
COMT Val158Met Val/Val local	variant
COMT Val158Met Val/Val genotype local	variant
COMT Val158Val genotype local	variant
concentration	phenotype
Continuous performance test	phenotype
cortisol	drug
cortisol release local	phenotype
cotinine	drug
CPT performance local	phenotype
craving	phenotype
decreased reward experience local	phenotype
depressed or sad mood local	phenotype
depression	phenotype
DEQ local	phenotype
DEQ assessments local	phenotype
difficulty concentrating	phenotype
difficulty quitting smoking	phenotype
dopamine	drug
drug dependence	phenotype
Drug Effects Questionnaire local	phenotype
drugs	drug
Drug Strength	phenotype
EA group	cohort
entacapone	drug
epinephrine local	drug
European ancestry	cohort
Faster reaction time local	phenotype
Feel Anxious local	phenotype
Feel Bad local	phenotype
Feel Down local	phenotype
Feel Drug Strength local	phenotype
Female smokers local	cohort
Female Smokers local	cohort
full sample	cohort
happiness	phenotype
healthy controls	cohort
heart rate	phenotype
high	phenotype
increased appetite	phenotype
insomnia	phenotype
irritability	phenotype
irritability/anger local	phenotype
Irritable local	phenotype
IV nicotine response local	phenotype
less happiness local	phenotype
Like the Drug local	phenotype
Male Smokers local	cohort
Marijuana craving local	phenotype
Mathematical Processing (MP) task local	phenotype
Math task performance local	phenotype
Math test performance local	phenotype
medically healthy participants local	cohort
men	cohort
Met/Met genotype	variant
Minnesota Nicotine Withdrawal Scale local	phenotype
MNWS local	phenotype
MP local	cohort
MP local	phenotype
N-back performance local	phenotype
negative affect	phenotype
negative affective state local	phenotype
Negative drug effects local	phenotype
Negative subjective effects local	phenotype
Negative subjective effects from IV nicotine local	phenotype
nicotine	drug
nicotine addiction	phenotype
nicotine administration local	phenotype
Nicotine Bitartrate local	drug
nicotine clearance	phenotype
nicotine exposure local	phenotype
Nicotine-induced nausea local	phenotype
nicotine metabolite ratio	phenotype
nicotine responses local	phenotype
NMR	drug
NMR values local	phenotype
Non-drug rewards local	phenotype
non-treatment-seeking cigarette smokers local	phenotype
norepinephrine	drug
nucleus accumbens	anatomy
NWSC local	phenotype
participants	cohort
poor response to smoking cessation treatments local	phenotype
Poor treatment response for smoking cessation local	phenotype
poor treatment response to smoking cessation treatments local	phenotype
positive affective state local	phenotype
Positive and Negative Affect Schedule	phenotype
Positive drug effects local	phenotype
prefrontal cortex	anatomy
prefrontal regions	anatomy
psychosis	phenotype
PureGene local	drug
race/ethnicity	phenotype
Reinforcing properties of nicotine	phenotype
response inhibition	phenotype
restlessness	phenotype
risk factor	phenotype
rs4680	variant
Running Memory Continuous Performance Test (CPT) local	phenotype
saline	drug
Salt-sensitive local	phenotype
Sedated local	phenotype
sex	phenotype
Shifting perceptual sets local	phenotype
smoking	phenotype
smoking abstinence	phenotype
smoking cessation	phenotype
Sodium excretion local	phenotype
Stimulated local	phenotype
stress	phenotype
Stroop task	phenotype
Stroop test local	drug
Stroop Test local	phenotype
subcortical regions	anatomy
subjective drug effects local	phenotype
subjective effects	phenotype
sustained attention	phenotype
throughput score local	phenotype
tobacco dependence	phenotype
tobacco use	phenotype
Tolcapone	drug
trans-3'-hydroxycotinine local	drug
Val158Met	gene
Val/Val genotype	gene
Want More local	phenotype
withdrawal	phenotype
withdrawal severity	phenotype
women	cohort
working memory	phenotype

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FKBP5 variation is associated with the acute and chronic effects of nicotine.	2015	25532758

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