Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women.
paper
Cited
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- Authors
- Colilla, Susan; Lerman, Caryn; Shields, Peter G; Jepson, Christopher; Rukstalis, Margaret; Berlin, Jesse; DeMichele, Angela; Bunin, Greta; Strom, Brian L; Rebbeck, Timothy R
- Year
- 2005
- Journal
- Pharmacogenetics and genomics
- PMID
- 15900212
- DOI
- 10.1097/01213011-200506000-00004
- PMCID
- PMC1262648
OBJECTIVES AND METHODS: The Val108/158Met polymorphism in the gene that encodes COMT, a dopamine metabolizing enzyme, results in a three- to four-fold reduction in COMT activity. To determine if the lower activity Met allele of COMT was associated with smoking cessation in women, we used two independent studies: a population-based case--control study and a nicotine replacement clinical trial. RESULTS: In the case--control study, women with two Met alleles were significantly more likely to be ex-smokers than current smokers [OR=1.82, 95% CI (1.05, 3.17), P=0.03]. In the nicotine replacement clinical trial, among women, the Met/Met genotype was associated with a higher probability of smoking cessation based on both point prevalence and prolonged abstinence outcomes [OR=2.96, 95% CI (1.07, 8.14), P=0.04; OR=3.23, 95% CI (1.13, 9.20), P=0.03, respectively]. CONCLUSIONS: This first report of a significant association between COMT Val108/158Met and smoking cessation suggests that COMT variation has an effect on smoking behavior in women.
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