The systolic blood pressure, diastolic blood pressure, and heart rate responses were dose-dependent such that responses to 1.0 mg nicotine>0.5 mg nicotine> saline (all p values<0.0001) (Figure 1). Significant findings for heart rate, and systolic and diastolic blood pressure are summarized in Table 1 and Figure 1. The BMI was not significant for heart rate or blood pressure. The NMR values were positively correlated with the nicotine-induced heart rate and systolic blood pressure (p<0.01).
