For all the DEQ assessments, the rating for the 1.0 mg nicotine or 0.5 mg nicotine does were > than for saline (all p values<0.05). For the rating of “Stimulated,” “High,” “Feel Drug Strength,” the ratings for the 1.0 mg nicotine> 0.5 mg nicotine (p<0.05). The NMR values were positively correlated with the ratings of “Stimulated” “High,” and “Feel Anxious” (p<0.05). The results for the DEQ items are summarized in Table 1 and Figure 2.