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Chunk #6 — 2. Materials and Methods — 2.3. Treatment Conditions — 2.3.1. Condition 1

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Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems.
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Serving as escalation control animals, the first two groups did not receive any surgical procedures and were divided into groups receiving either one-month of chronic intermittent ethanol vapor (n=5) or air exposure (n=5).