Chunk #7 — 2. Materials and Methods — 2.3. Treatment Conditions — 2.3.2. Condition 2

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Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems.

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The chronic treatment animals were implanted with osmotic minipumps (OMP; 42-day pumps; Alzet, Cupertino, CA) that were connected to unilateral cannulae (28 gauge; Alzet, Cupertino, CA) targeting one lateral ventricle. One group received chronic FN-439 infusion (n=7,1.5 μg/hr in 0.15μl/hr), whereas the other received chronic aCSF (n=7; 0.15μl/hr) during the dependence induction period and post-vapor self-administration sessions.