Chunk #8 — 2. Materials and Methods — 2.3. Treatment Conditions — 2.3.3. Condition 3

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Plasticity associated with escalated operant ethanol self-administration during acute withdrawal in ethanol-dependent rats requires intact matrix metalloproteinase systems.

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yes

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The acute treatment animals were implanted with bilateral guide cannulae (22 gauge; Plastics One, Roanoke, VA) targeting the lateral ventricles and, following dependence induction, were designated to receive 35μg FN-439 (17.5/side; n=7) or aCSF (n=7) 15 minutes prior to and 45 miinutes following the post-dependence ethanol self-administration sessions.