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Chunk #17 — METHODS — Follow-ups of probands, enrollment of offspring, and follow-ups

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Cross-sectional and prospective associations of drinking characteristics with scores from the Self-Report of the Effects of Alcohol questionnaire and findings from alcohol challenges.
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The evaluations also included the Impulsiveness Subscale of the Karolinska Scales of Personality and the Zuckerman Sensation Seeking Scale (Gustavsson et al., 2000; Schuckit, 2018; Schuckit et al., 2016, 2020a,b; Zuckerman, 1978). The proband’s evaluation at about age 35 was the first follow-up after the development of the SRE retrospective questionnaire structured to measure LR as the number of standard drinks required for up to 4 effects (first effect, feeling dizzy or slurring speech, unstable standing, and unplanned falling asleep). Here, the more the drinks required for effects, the lower the LR per drink. As described in Introduction, the SRE score is the average of the drinks needed for up to 4 effects: the approximate first 5 times of drinking on one’s own (SRE-5), the most recent 3 months of drinking (SRE-3), the period of heaviest drinking (SRE-H), and a total average across all time frames (SRE-T). The score for each period is generated by summing the drinks in that period needed across effects actually experienced divided by the number of effects endorsed, and the SRE total (SRE-T) score is