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Chunk #69 — Methods — Differential gene and cellular state expression analysis in humans

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Single nuclei transcriptomics in human and non-human primate striatum in opioid use disorder.
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We estimated the effect of morphine treatment vs. no-morphine individuals across each annotated cell type, across neuronal subtypes (Neuron), across glial types (Glia), and across all cell types (All). For the first set of hypotheses at the annotated cell type level, we used the simple contrast CelltypeA_morphine - CelltypeA_control.