The 21 categories with q<0.25 in the i-GSEA4GWAS analysis are presented in Table 2; complete results are available in Table S3. The top gene set, alpha-linolenic acid metabolism, included 8 genes (of 15 in the gene set) that span variants nominally associated with the alcohol problems factor score. Ontologies related to immune function/inflammation response (e.g., negative regulation of cytokine biosynthetic process, interferon gamma pathway) were also implicated in these analyses. Multiple ontologies related to nervous system development or function were over-represented, with modest overlap in the gene members across these categories.
