Schizophrenia is a common neuropsychiatric disorder that is characterized by positive symptoms such as delusions, paranoia and hallucinations, negative symptoms including apathy, anhedonia, and social withdrawal, and extensive cognitive impairments that may have the greatest impact on overall function [1],[2]. While current antipsychotic drug treatments control positive symptoms in most patients, negative symptoms and cognitive impairments are much less improved by these agents [3]. A possible way to improve the treatment of schizophrenia is to identify genetic risk factors that might elucidate the underlying pathophysiological bases as well as help to subclassify patients at a molecular level in a manner helpful to therapy.
