Nonetheless, the results highlight the sensitivity of the NOGO P3 to the negative effects of alcoholism, with the NOGO P3 amplitude significantly smaller in alcoholics than controls at Cz, the site at which it is optimally recorded (Fallgatter et al. 1997). Wavelet-based time–frequency analysis of the time interval surrounding the P3 peak at Cz revealed that total δ power was smaller in alcoholics than controls and significantly related to transverse diffusivity in the cingulate bundles. Although P3 in the GO condition did not differentiate alcoholics from controls, P3 amplitude was smaller and P3 latency longer with older age in the combined samples. Reduced P3 amplitude is a robust finding in alcoholics and those at risk for alcoholism (see Porjesz and Begleiter (2003) and Porjesz et al. (2005) for reviews). Most studies have focused on the P3 component associated with correct determination of a previously identified target stimulus in an oddball paradigm. However, the smaller NOGO P3 in alcoholics compared to controls is consistent with previous studies (Ceballos et al. 2003; Cohen et al. 1997b; Ford et al. 1991; Hada et
