Secondary analyses with APOE genotype (presence vs. absence of ε4 allele) as a covariate or moderator of the association between personality and incident AD were performed for the subset of 1472 participants with available APOE genotype. We also repeated the analyses excluding individuals younger than 50 years at initial examination, or those who developed AD within two years after the initial personality assessment. Finally, we tested whether sex moderated the association between personality traits and incident AD. The analyses were conducted using SPSS statistical software.
