at the outset that the study was designed to capture normative adolescent development and was not originally conceptualized as a study of substance use or alcohol abstinence. However, a subsample of the full range of study participants is particularly informative in relation to longitudinal trajectories associated with later substance use given its overall health and low-risk nature. This report focuses on that subsample (n = 55), comprised of individuals who reported no experience with alcohol or drugs at baseline enrollment. That is, they had never ingested even a single drink. These 55 individuals were aged 14 to 19 at baseline, representing the group that was most likely to initiate alcohol use over the follow-up interval.