Chunk #63 — THEORETICAL DERIVATIONS — IMPACT OF LD ON POWER — Trend test

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Disease model distortion in association studies.

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yes

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Comparing η1 and η2, we see that a sample size of NB = NA/r2 is required to achieve the same power as typing the causal SNP directly. This is essentially the same derivation as shown in Pritchard and Przeworski [2001], but here based on the Wald test.