Chunk #64 — THEORETICAL DERIVATIONS — IMPACT OF LD ON POWER — Deviation test

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Disease model distortion in association studies.

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The Wald test for the dominance parameter amounts to comparing the multiplicative and general models and thus tests for a deviation from the multiplicative model. We therefore refer to this as the deviation test. Applying the same idea as above, now using Equations (11) and (5), gives the noncentrality parameters,