These authors replicated their earlier finding that the ADH1B 48H allele is protective against alcohol-related UADT cancer. This finding was replicated not only in the central European sample, but also in the two other study populations. The overall odds ratio (OR) for the ADH1B R48H allele was 0.56, with a 95 per cent confidence interval (CI) of 0.47-0.66. An interesting additional finding from this work is that a polymorphism in ADH7 (rs1573496; G92A) is protective against UADT cancers from alcohol consumption. As with ADH1B, the protective effect of the ADH7 variant was consistently observed across all three study populations. For this allele, the overall OR was 0.68 (95 per cent CI 0.60-0.78). The two protective ADH alleles had an additive effect, in that the OR for both alleles was 0.45 (95 per cent CI 0.34-0.60).
