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Alleles of alcohol and acetaldehyde metabolism genes modulate susceptibility to oesophageal cancer from alcohol consumption.
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Earlier in 2008, the same group both confirmed and substantially extended the results presented in its 2006 publication. In this new study,[5] the authors investigated six ADH genetic variants in relation to alcohol-related UADT cancer in a combined analysis of three different study populations: one from a central European sample, one from western Europe and one from Latin America. In total, they examined 3,876 cancer cases and over 5,278 controls.