There are also reasons to believe that the support of long-range connectivity, namely that of white matter, is also abnormal in schizophrenia. Although there is no direct proof, it is probable that the dilatation of the anterior horn of the lateral ventricle, one of the most robust findings in schizophrenia,13 has something to do with a volume reduction of frontal white matter. Here again, it seems to be a case of hypotrophy as well as atrophy.“ Voxel-based morphometry has mainly highlighted the probability of a reduction in white matter in the subcortical frontal region and the corpus callosum. Abnormal
