To examine the role of BAF53b in memory, BAF53bΔHD and Baf53b+/− het mice were tested for both long- and short-term memory for object location (OLM; Fig. 2A) and object recognition (ORM; Fig. 2D). Wildtype mice exhibited long-term OLM (Fig. 2B & 2C; as measured by preference for the novel location over the familiar location and calculated as the discrimination index). However, both the high and low expressing lines of BAF53bΔHD mice exhibited significantly reduced discrimination indices compared to wildtype littermates (Fig. 2B). Similar to the BAF53bΔHD lines, Baf53b+/− het mice also exhibited significant deficits in long-term OLM (Fig. 2C). In contrast to the long-term memory deficits, short-term OLM (tested at 90 min) was normal in BAF53bΔHD mice (Supplemental Fig. S3B) and Baf53b+/− het mice (Supplemental Fig. S3C) as compared to respective wildtype littermates. Deficits in long-term memory formation were also found in the object recognition paradigm (Fig. 2D). Wildtype mice exhibited normal long-term ORM (as measured by preference for the novel object over the familiar object and calculated as the discrimination index). Both the BAF53bΔHD high and low expressing lines
