cells were derived in vivo. We applaud the excitement and cheer the general enthusiasm that the work has deservedly generated. What is most exciting is that the combined effort is finally a critical mass and as a result has caught the attention of many new scientists who are emphasizing the importance of 3D culture by pointing out the relevance and the significance of this work to clinical research. However, the term “organoid” is being treated, or has come to imply, that this is a completely new field, separate from what several scientists from as early as the turn of the previous century have been engaged in for years, essentially in isolation, introducing the term 3D cultures, beginning the field of microenvironment, and pointing out the significance of tissue architecture.
