Organoids: A historical perspective of thinking in three dimensions.
paper
Cited
Public
- Authors
- Simian, Marina; Bissell, Mina J
- Year
- 2017
- Journal
- The Journal of cell biology
- PMID
- 28031422
- DOI
- 10.1083/jcb.201610056
- PMCID
- PMC5223613
In the last ten years, there has been a dramatic surge in the number of publications where single or groups of cells are grown in substrata that have elements of basement membrane leading to the formation of tissue-like structures referred to as organoids. However, this field of research began many decades ago, when the pioneers of cell culture began to ask questions we still ask today: How does organogenesis occur? How do signals integrate to make such vastly different tissues and organs given that the sequence of the genome in our trillions of cells is identical? Here, we summarize how work over the past century generated the conceptual framework that has allowed us to make progress in the understanding of tissue-specific morphogenetic programs. The development of cell culture systems that provide accurate and physiologically relevant models are proving to be key in establishing appropriate platforms for the development of new therapeutic strategies.
Number of publications per year on organoids and 3D cell cultures according to PubMed. The number of publications per year is graphed for the following PubMed searches: βorganoids [tw]β is shown in red squares, βorganoid [tw]β is shown in blue circles, and β3D cell cultureβ is shown in green triangles. Figure courtesy of Neil Smith.
Timeline of techniques and experiments leading to the current organoid field. The images shown in the 1975β1977 box are from Lyon et al. (2015), and are displayed under the terms of a Creative Commons License. Figure courtesy of Neil Smith.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | 2019 | 30087005 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Advances in three-dimensional fish cell models for aquatic toxicology. | Zhang PP et al. | β | 2026 | β |
| An <i>Ex Vivo</i> Mini-Tumor Culture Protocol for Evaluating Individualized Efficacy of Chemotherapy and Immunotherapy. | Fu Y et al. | β | 2026 | β |
| Cell-Based Computational Models of Organoids: A Systematic Review. | Neagu M et al. | β | 2026 | β |
| Human milk oligosaccharides modulate inflammatory responses and lipid metabolism in a human intestinal organoid model. | Slater E et al. | β | 2026 | β |
| Longitudinal prediction of drug response in high-grade serous ovarian cancer organoid cultures aligning with clinical responses. | Cavarzerani E et al. | β | 2026 | β |
| Mastering Organoid Growth: A Complete Guide to Overcoming Methodological Challenges. | Jiao C et al. | β | 2026 | β |
| Mechanopharmacology: in vitro techniques to advance drug discovery. | Zielinski JL et al. | β | 2026 | β |
| Organoid models in viral hepatitis, primary liver cancer, and non-alcoholic fatty liver disease: Advances and challenges. | Han YQ et al. | β | 2026 | β |
| Stromal vascular fraction self-assembles vascularized osteogenic organoids with immunomodulatory functions. | Wu J et al. | β | 2026 | β |
| Therapeutic strategy for cervical gastric-type adenocarcinoma by targeting CLU to relieve CLU-associated stress and sensitize chemotherapy. | Wu T et al. | β | 2026 | β |
| Towards functional precision medicine? Evidence standards of organoids as patient-specific models. | Green S et al. | β | 2026 | β |
| 3D collagen high-throughput screen identifies drugs that induce epithelial polarity and enhance chemotherapy response in colorectal cancer. | Harmych SJ et al. | β | 2025 | β |
| A Comprehensive Review on Utilizing Human Brain Organoids to Study Neuroinflammation in Neurological Disorders. | Rubio AD et al. | β | 2025 | β |
| A visualized and quercetin-optimized three-dimensional culture model of mouse ovaries derived from fetal gonads. | Cui M et al. | β | 2025 | β |
| Beyond mimicry: a framework for evaluating genuine intelligence in artificial systems. | Niazi SK | β | 2025 | β |
| Biomaterial-assisted organoid technology for disease modeling and drug screening. | Shao Y et al. | β | 2025 | β |
| Bridging the gap between tumor and disease: Innovating cancer and glioma models. | Cirigliano SM et al. | β | 2025 | β |
| Bridging the gap in Parkinson's disease research: from general pathophysiology to advanced 3d cell culture models. | Keles B et al. | β | 2025 | β |
| Current Organoid Culture Systems in Pancreatic Cancer. | Liu L et al. | β | 2025 | β |
| Digital PCR characterizes epithelial cell populations in murine duodenal organoids. | Acosta-Virgen K et al. | β | 2025 | β |
| Dynamic Hydrogels with Tunable Mechanics for 3D Organoid Derivation. | Xie X et al. | β | 2025 | β |
| Establishment of a patient-derived 3D in vitro meningioma model in xeno-free hydrogel for clinical applications. | Andersen MS et al. | β | 2025 | β |
| Exploiting Cancer Dormancy Signaling Mechanisms in Epithelial Ovarian Cancer Through Spheroid and Organoid Analysis. | Tomas EJ et al. | β | 2025 | β |
| FNA biopsy of breast specimens effectively harvests cells for patient-derived organoids modeling ductal carcinoma in situ. | Ye J et al. | β | 2025 | β |
| Global landscape of hepatic organoid research: A bibliometric and visual study. | Li T et al. | β | 2025 | β |
| High-throughput solutions in tumor organoids: from culture to drug screening. | Zuo J et al. | β | 2025 | β |
| Human colon organoid differentiation from induced pluripotent stem cells using an improved method. | Lee IT et al. | β | 2025 | β |
| Injectable thermosensitive methylcellulose-carboxymethyl chitosan hydrogel for the delivery of human amniotic fluid mesenchymal stromal cell spheroids in cartilage regeneration. | Zuliani CC et al. | β | 2025 | β |
| Innovative Therapeutic Approach Targeting Colon Cancer Stem Cells: Transitional Cold Atmospheric Plasma. | Soulat A et al. | β | 2025 | β |
| Integration of Organoids With CRISPR Screens: A Narrative Review. | Mukhare R et al. | β | 2025 | β |
| In vitro derivation of midbrain dopaminergic neurons from porcine embryonic stem cells in multi-dimensional conditions. | Choi H et al. | β | 2025 | β |
| Liver organoids uncover tire-derived 6-PPDQ-induced hepatotoxicity of: A preliminary application of environmental toxicology and safety assessment. | Ge Y et al. | β | 2025 | β |
| Modeling human placental biology: a review of organoid technologies. | Bashi A et al. | β | 2025 | β |
| Optimal Production of 3D Neuronal Lineage Population by Morphological Classification. | Choi JH et al. | β | 2025 | β |
| Organoid Ethical Typology: varieties of three-dimensional stem cell constructs and the many issues they raise in bioethics. | Gaillard M et al. | β | 2025 | β |
| Organoid in droplet: Production of uniform pancreatic cancer organoids from single cells. | Liu H et al. | β | 2025 | β |
| Periosteum Organoid: Biomimetic Design Inspired From the Bone Healing Process. | Hao S et al. | β | 2025 | β |
| Potential Implications of Organoids in Dental Research. | Sharma D et al. | β | 2025 | β |
| Recent Progress in 2D, 3D, and On-a-Chip Models of the Placenta. | Harrison AM et al. | β | 2025 | β |
| Revisiting the biophysical aspects of extracellular-matrix-mimicking hydrogels: what cells see <i>vs.</i> what cells feel. | Sui J et al. | β | 2025 | β |
| Revolutionizing cardiovascular research: Human organoids as a Beacon of hope for understanding and treating cardiovascular diseases. | Li J et al. | β | 2025 | β |
| Silent saboteurs: How microplastics disrupt stem cells and tissue regeneration. | Zheng JH et al. | β | 2025 | β |
| Strategies to overcome the limitations of current organoid technology - engineered organoids. | Fan X et al. | β | 2025 | β |
| The Use of Organoid Cultures in Advancing Nutrition Research. | Menikdiwela KR et al. | β | 2025 | β |
| Three-Dimensional Culture System: A New Frontier in Cancer Research, Drug Discovery, and Stem Cell-Based Therapy. | Marconi GD et al. | β | 2025 | β |
| Three-dimensional models: from cell culture to Patient-Derived Organoid and its application to future liposarcoma research. | Tahara S et al. | β | 2025 | β |
| Untangling the Molecular Mechanisms Contributing to Autism Spectrum Disorder Using Stem Cells. | Mattingly Z et al. | β | 2025 | β |
| 3D Cell Culture: Techniques For and Beyond Organoid Applications. | Sumbalova Koledova Z | β | 2024 | β |
| A Co-Culture System for Studying Cellular Interactions in Vascular Disease. | Padmanaban AM et al. | β | 2024 | β |
| A comprehensive review on 3D tissue models: Biofabrication technologies and preclinical applications. | Xie R et al. | β | 2024 | β |
| A Decision Tree to Guide Human and Mouse Mammary Organoid Model Selection. | Caruso M et al. | β | 2024 | β |
| A theory of evolutionary dynamics on any complex population structure reveals stem cell niche architecture as a spatial suppressor of selection. | Kuo YP et al. | β | 2024 | β |
| Bidirectionally validated <i>in silico</i> and <i>in vitro</i> formation of specific depth zone-derived chondrocyte spheroids and clusters. | Takada E et al. | β | 2024 | β |
| Bioprinting of Cells, Organoids and Organs-on-a-Chip Together with Hydrogels Improves Structural and Mechanical Cues. | Mierke CT | β | 2024 | β |
| Bioprinting Using Organ Building Blocks: Spheroids, Organoids, and Assembloids. | Baptista LS et al. | β | 2024 | β |
| Blastoid: The future of human development in the laboratory. | Choi HK et al. | β | 2024 | β |
| Bovine adipose tissue-derived mesenchymal stem cells self-assemble with testicular cells and integrates and modifies the structure of a testicular organoids. | Cortez J et al. | β | 2024 | β |
| Cellular collusion: cracking the code of immunosuppression and chemo resistance in PDAC. | Musiu C et al. | β | 2024 | β |
| Cervical extracellular matrix hydrogel optimizes tumor heterogeneity of cervical squamous cell carcinoma organoids. | Song H et al. | β | 2024 | β |
| Characterization of a Syngeneic Orthotopic Model of Cholangiocarcinoma by [<sup>18</sup>F]FDG-PET/MRI. | Zachhuber L et al. | β | 2024 | β |
| Construction methods and latest applications of kidney cancer organoids. | Li Z et al. | β | 2024 | β |
| Dynamic models of human development and concepts of the individual. | Hyun I | β | 2024 | β |
| Engineered 3D ex vivo models to recapitulate the complex stromal and immune interactions within the tumor microenvironment. | Ravi K et al. | β | 2024 | β |
| Establishment of patient-derived organoids and a characterization based drug discovery platform for treatment of gastric cancer. | Chen G et al. | β | 2024 | β |
| Exploring the impact of microfluidic chip structure on the efficacy of three-dimensional tumor microspheres cultivation. | Jiang Y et al. | β | 2024 | β |
| Global Literature Analysis of Organoid and Organ-on-Chip Research. | Shoji JY et al. | β | 2024 | β |
| Growth pattern of de novo small clusters of colorectal cancer is regulated by Notch signaling at detachment. | Lin YK et al. | β | 2024 | β |
| Hallmarks of stemness in mammalian tissues. | Beumer J et al. | β | 2024 | β |
| Hepatocellular-Carcinoma-Derived Organoids: Innovation in Cancer Research. | Airola C et al. | β | 2024 | β |
| HIF2Ξ±-dependent Dock4/Rac1-signaling regulates formation of adherens junctions and cell polarity in normoxia. | Raykhel I et al. | β | 2024 | β |
| Human breast tissue engineering in health and disease. | Buchholz MB et al. | β | 2024 | β |
| Inhibition of autocrine HGF maturation overcomes cetuximab resistance in colorectal cancer. | Jones VT et al. | β | 2024 | β |
| Insights on Three Dimensional Organoid Studies for Stem Cell Therapy in Regenerative Medicine. | Mulaudzi PE et al. | β | 2024 | β |
| In-situ monitoring of cellular H<sub>2</sub>O<sub>2</sub> within 3D cell clusters using conductive scaffolds. | Zhu L et al. | β | 2024 | β |
| Intestinal organoid modeling: bridging the gap from experimental model to clinical translation. | Liu T et al. | β | 2024 | β |
| Mechanical effects modulate drug resistance in MCF-7-derived organoids: Insights into the wnt/Ξ²-catenin pathway. | Karimifard SA et al. | β | 2024 | β |
| Mesothelioma-Associated Fibroblasts Modulate the Response of Mesothelioma Patient-Derived Organoids to Chemotherapy via Interleukin-6. | Cioce M et al. | β | 2024 | β |
| Microphysiological systems for human aging research. | Park S et al. | β | 2024 | β |
| Modelling cancer metabolism inΒ vitro: current improvements and future challenges. | Dragic H et al. | β | 2024 | β |
| Monte Carlo simulation-guided design for size-tuned tumor spheroid formation in 3D printed microwells. | EΕ I et al. | β | 2024 | β |
| Oral host-microbe interactions investigated in 3D organotypic models. | Shang L et al. | β | 2024 | β |
| Organoid Cultures for the Study of Mammary Biology and Breast Cancer: The Promise and Challenges. | Muthuswamy SK et al. | β | 2024 | β |
| Organoids as a new approach for improving pediatric cancer research. | Lampis S et al. | β | 2024 | β |
| Organoids-On-a-Chip for Personalized Precision Medicine. | Man Y et al. | β | 2024 | β |
| Organ-On-A-Chip Devices: Technology Progress and Challenges. | Obeid PJ et al. | β | 2024 | β |
| Phenotypic screening in Organ-on-a-Chip systems: a 1537 kinase inhibitor library screen on a 3D angiogenesis assay. | Soragni C et al. | β | 2024 | β |
| Recent Advances in Graphene Oxide-Based on Organoid Culture as Disease Model and Cell Behavior - A Systematic Literature Review. | Sulaksono HLS et al. | β | 2024 | β |
| Regulation of cell fate by cell imprinting approach in vitro. | Hasannejad F et al. | β | 2024 | β |
| Revolutionizing pancreatic islet organoid transplants: Improving engraftment and exploring future frontiers. | Abraham N et al. | β | 2024 | β |
| Spatial Transcriptomics: A Powerful Tool in Disease Understanding and Drug Discovery. | Cao J et al. | β | 2024 | β |
| Species Choice and Model Use: Reviving Research on Human Development. | Hopwood N | β | 2024 | β |
| Substrate topography affects PC12 cell differentiation through mechanotransduction mechanisms. | Papadimitriou L et al. | β | 2024 | β |
| TGF-Ξ² induces matrisome pathological alterations and EMT in patient-derived prostate cancer tumoroids. | Fernandes S et al. | β | 2024 | β |
| The porcine islet-derived organoid showed the characteristics as pancreatic duct. | Sakata N et al. | β | 2024 | β |
| The progressive trend of modeling and drug screening systems of breast cancer bone metastasis. | Kolahi Azar H et al. | β | 2024 | β |
| Three-Dimensional Bioprinting of Organoids: Past, Present, and Prospective. | Cabral M et al. | β | 2024 | β |
| Three-Dimensional Cultivation a Valuable Tool for Modelling Canine Mammary Gland Tumour Behaviour In Vitro. | Huniadi M et al. | β | 2024 | β |
| Unravelling the complexities of resistance mechanism in pancreatic cancer: Insights from in vitro and ex-vivo model systems. | Lencioni G et al. | β | 2024 | β |
| Viscoelasticity of Hyaluronic Acid Hydrogels Regulates Human Pluripotent Stem Cell-derived Spinal Cord Organoid Patterning and Vascularization. | Chen X et al. | β | 2024 | β |
| 3D Biomimetic Models to Reconstitute Tumor Microenvironment In Vitro: Spheroids, Organoids, and Tumor-on-a-Chip. | Li W et al. | β | 2023 | β |
| 3D hydrogel/ bioactive glass scaffolds in bone tissue engineering: Status and future opportunities. | Aldhaher A et al. | β | 2023 | β |
| 3D Organoids for Regenerative Endodontics. | Li FC et al. | β | 2023 | β |
| A decade of liver organoids: Advances in disease modeling. | Liu Y et al. | β | 2023 | β |
| Advancement of Organoid Technology in Regenerative Medicine. | Arjmand B et al. | β | 2023 | β |
| Advances in Cystic Fibrosis Research in Qatar: A Commentary. | Hammoudeh S et al. | β | 2023 | β |
| Advantages and Potential Benefits of Using Organoids in Nanotoxicology. | Nikonorova VG et al. | β | 2023 | β |
| Analysis of organoid and immune cell co-cultures by machine learning-empowered image cytometry. | StΓΌve P et al. | β | 2023 | β |
| A platform for modular assembly and feeding of micro-organoids on standard Petri dishes. | Nebuloni F et al. | β | 2023 | β |
| A review on in vitro model of the blood-brain barrier (BBB) based on hCMEC/D3 cells. | Qi D et al. | β | 2023 | β |
| Cell state transitions: catch them if you can. | Miroshnikova YA et al. | β | 2023 | β |
| Contemporary enterovirus-D68 isolates infect human spinal cord organoids. | Aguglia G et al. | β | 2023 | β |
| Current trends and future prospects of drug repositioning in gastrointestinal oncology. | Fatemi N et al. | β | 2023 | β |
| Customized liver organoids as an advanced <i>in vitro</i> modeling and drug discovery platform for non-alcoholic fatty liver diseases. | Han DW et al. | β | 2023 | β |
| Drug screening at single-organoid resolution via bioprinting and interferometry. | Tebon PJ et al. | β | 2023 | β |
| Effect of three-dimensional collagen membrane culture and presence of cumulus cells on maturation of bovine oocytes. | Ribeiro Junior JP et al. | β | 2023 | β |
| Emerging trends in the methodology of environmental toxicology: 3D cell culture and its applications. | Wang H et al. | β | 2023 | β |
| Engineered organoids for biomedical applications. | Roberto de Barros N et al. | β | 2023 | β |
| ER-/PR+ breast cancer is controlled more effectively with an inflammatory inhibitor than hormonal inhibitor. | Song C et al. | β | 2023 | β |
| Establishment and Culture of Patient-Derived Breast Organoids. | Aggarwal D et al. | β | 2023 | β |
| [For a good understanding and use of the term "organoids"]. | Chneiweiss H et al. | β | 2023 | β |
| <i>In vitro</i> functional models for human liver diseases and drug screening: beyond animal testing. | Paradiso A et al. | β | 2023 | β |
| Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research. | van Amerongen R et al. | β | 2023 | β |
| Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer. | Xu Z et al. | β | 2023 | β |
| Insights into high-grade serous carcinoma pathobiology using three-dimensional culture model systems. | Tomas E et al. | β | 2023 | β |
| In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models. | Lee SY et al. | β | 2023 | β |
| Light and electron microscopy continuum-resolution imaging of 3D cell cultures. | D'Imprima E et al. | β | 2023 | β |
| Mathematical and computational models in spheroid-based biofabrication. | Arjoca S et al. | β | 2023 | β |
| Mini-organs with big impact: Organoids in liver cancer studies. | Khawar MB et al. | β | 2023 | β |
| Modeling Liver Development and Disease in a Dish. | Iqbal W et al. | β | 2023 | β |
| Morphogenesis and development of human telencephalic organoids in the absence and presence of exogenous extracellular matrix. | Martins-Costa C et al. | β | 2023 | β |
| NAFLD-Related HCC: Focus on the Latest Relevant Preclinical Models. | Fang J et al. | β | 2023 | β |
| Organoids as complex (bio)systems. | Fernandes TG | β | 2023 | β |
| Organoids in the Clinic: A Systematic Review of Outcomes. | Hofmann B et al. | β | 2023 | β |
| Ovarian Cancer Patient-Derived Organoid Models for Pre-Clinical Drug Testing. | Fashemi BE et al. | β | 2023 | β |
| Polarity in breast development and cancer. | Whitford MKM et al. | β | 2023 | β |
| Preclinical models for drug discovery for metastatic disease. | Wakefield L et al. | β | 2023 | β |
| Prostate organoids: emerging experimental tools for translational research. | Beshiri M et al. | β | 2023 | β |
| Recent Advances in Organ-on-Chips Integrated with Bioprinting Technologies for Drug Screening. | Tabatabaei Rezaei N et al. | β | 2023 | β |
| Reimagining Cancer: Moving from the Cellular to the Tissue Level. | Demicheli R et al. | β | 2023 | β |
| Reuniting philosophy and science to advance cancer research. | Pradeu T et al. | β | 2023 | β |
| Salivary gland bioengineering - yesterday, today, tomorrow! | Iyer J et al. | β | 2023 | β |
| Scientific Advancements That Empower Us to Understand CRS Pathophysiology. | Qureshi HA et al. | β | 2023 | β |
| The Three-Dimensional In Vitro Cell Culture Models in the Study of Oral Cancer Immune Microenvironment. | Dalir Abdolahinia E et al. | β | 2023 | β |
| Thinking in 3 dimensions: philosophies of the microenvironment in organoids and organs-on-chip. | Caianiello S et al. | β | 2023 | β |
| Three-Dimensional In Vitro Tumor Spheroid Models for Evaluation of Anticancer Therapy: Recent Updates. | Nayak P et al. | β | 2023 | β |
| TORNADO-seq: A Protocol for High-Throughput Targeted RNA-seq-Based Drug Screening in Organoids. | Norkin M et al. | β | 2023 | β |
| Toward better drug development: Three-dimensional bioprinting in toxicological research. | SzΕ±cs D et al. | β | 2023 | β |
| WITHDRAWN: In Vitro three-dimensional (3D) cell culture tools for spheroid and organoid models. | Lee SY et al. | β | 2023 | β |
| 3D modeling in cancer studies. | Atat OE et al. | β | 2022 | β |
| [3D Tumor organoid models produced by cellular capsules technology CCT]. | Recher G et al. | β | 2022 | β |
| Accelerating cardiovascular research: recent advances in translational 2D and 3D heart models. | Mohr E et al. | β | 2022 | β |
| A comprehensive overview of CRISPR/Cas 9 technology and application thereof in drug discovery. | Khurana A et al. | β | 2022 | β |
| Alternative strategies in cardiac preclinical research and new clinical trial formats. | Kreutzer FP et al. | β | 2022 | β |
| Applications of Brain Organoids for Infectious Diseases. | Fan W et al. | β | 2022 | β |
| A practical guide for the analysis, standardization and interpretation of oxygen consumption measurements. | Divakaruni AS et al. | β | 2022 | β |
| A simple method to generate human airway epithelial organoids with externally orientated apical membranes. | Boecking CA et al. | β | 2022 | β |
| A Spatiotemporal Microenvironment Model to Improve Design of a Three-Dimensional Bioreactor for Red Cell Production. | Allenby MC et al. | β | 2022 | β |
| Baseline and time-updated factors in preclinical development of anionic dendrimers as successful anti-HIV-1 vaginal microbicides. | RodrΓguez-Izquierdo I et al. | β | 2022 | β |
| Bilirubin-Induced Neurological Damage: Current and Emerging iPSC-Derived Brain Organoid Models. | Pranty AI et al. | β | 2022 | β |
| Central nervous system organoids for modeling neurodegenerative diseases. | Hou PS et al. | β | 2022 | β |
| Challenges and recent trends with the development of hydrogel fiber for biomedical applications. | Ansar R et al. | β | 2022 | β |
| Characterization of human nasal organoids from chronic rhinosinusitis patients. | Ramezanpour M et al. | β | 2022 | β |
| Clinical applications of 3D normal and breast cancer organoids: A review of concepts and methods. | Lewis SM et al. | β | 2022 | β |
| Comparison of the Response to the CXCR4 Antagonist AMD3100 during the Development of Retinal Organoids Derived from ES Cells and Zebrafish Retina. | Wu Y et al. | β | 2022 | β |
| Current Research Trends in the Application of In Vitro Three-Dimensional Models of Liver Cells. | Yun C et al. | β | 2022 | β |
| Current strategies with implementation of three-dimensional cell culture: the challenge of quantification. | Temple J et al. | β | 2022 | β |
| Designing a Biomaterial Approach to Control the Adaptive Response to a Skin Injury. | Feldman D | β | 2022 | β |
| Development of Human Pituitary Neuroendocrine Tumor Organoids to Facilitate Effective Targeted Treatments of Cushing's Disease. | Chakrabarti J et al. | β | 2022 | β |
| Encapsulation of Cells in a Collagen Matrix Surrounded by an Alginate Hydrogel Shell for 3D Cell Culture. | Bouhlel W et al. | β | 2022 | β |
| Engineering the Extracellular Matrix for Organoid Culture. | Heo JH et al. | β | 2022 | β |
| Everything You Always Wanted to Know About Organoid-Based Models (and Never Dared to Ask). | Hautefort I et al. | β | 2022 | β |
| Gellan Gum Is a Suitable Biomaterial for Manual and Bioprinted Setup of Long-Term Stable, Functional 3D-Adipose Tissue Models. | Albrecht FB et al. | β | 2022 | β |
| High-throughput formation and image-based analysis of basal-in mammary organoids in 384-well plates. | Lee S et al. | β | 2022 | β |
| Human Endometrial Organoids: Recent Research Progress and Potential Applications. | Lou L et al. | β | 2022 | β |
| Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation. | Wu M et al. | β | 2022 | β |
| Intestinal Organoids: New Tools to Comprehend the Virulence of Bacterial Foodborne Pathogens. | Aguirre Garcia M et al. | β | 2022 | β |
| Knowledge graphs of ethical concerns of cerebral organoids. | Ding L et al. | β | 2022 | β |
| Lung Organoids as Model to Study SARS-CoV-2 Infection. | Peng L et al. | β | 2022 | β |
| Microarrayed human bone marrow organoids for modeling blood stem cell dynamics. | Giger S et al. | β | 2022 | β |
| Multimodal microscale mechanical mapping of cancer cells in complex microenvironments. | NikoliΔ M et al. | β | 2022 | β |
| Myoepithelial progenitors as founder cells of hyperplastic human breast lesions upon PIK3CA transformation. | Goldhammer N et al. | β | 2022 | β |
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| Organoids: A Promising Preclinical Model for Pancreatic Cancer Research. | Navarro-Serer B et al. | β | 2022 | β |
| Organoids as research models for hepatocellular carcinoma. | Yu JH et al. | β | 2022 | β |
| Organoids: Expanding Applications Enabled by Emerging Technologies: Organoids: emerging technologies and applications. | Pak C et al. | β | 2022 | β |
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| Patient-Derived Bladder Cancer Organoid Models in Tumor Biology and Drug Testing: A Systematic Review. | Medle B et al. | β | 2022 | β |
| Preparation of Spheroids from Primary Pig Cells in a Mid-Scale Bioreactor Retaining Their Myogenic Potential. | Stange K et al. | β | 2022 | β |
| Preparing ductal epithelial organoids for high-spatial-resolution molecular profiling using mass spectrometry imaging. | Bakker B et al. | β | 2022 | β |
| Recent advances in organoid engineering: A comprehensive review. | Unagolla JM et al. | β | 2022 | β |
| Reciprocity of Cell Mechanics with Extracellular Stimuli: Emerging Opportunities for Translational Medicine. | Li Y et al. | β | 2022 | β |
| Soluble ECM promotes organotypic formation in lung alveolar model. | Valdoz JC et al. | β | 2022 | β |
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| The neurovascular unit in leukodystrophies: towards solving the puzzle. | Zarekiani P et al. | β | 2022 | β |
| The potential application of organoids in breast cancer research and treatment. | Ebrahimi N et al. | β | 2022 | β |
| The Promise of Patient-Derived Colon Organoids to Model Ulcerative Colitis. | Ojo BA et al. | β | 2022 | β |
| Three-Dimensional Organoids as a Model to Study Nonalcoholic Fatty Liver Disease. | Park Y et al. | β | 2022 | β |
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| What can biofabrication do for space and what can space do for biofabrication? | Moroni L et al. | β | 2022 | β |
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| Bioinformatic Approaches to Validation and Functional Analysis of 3D Lung Cancer Models. | Li PJ et al. | β | 2021 | β |
| Brain organoids: an ensemble of bioassays to investigate human neurodevelopment and disease. | Sidhaye J et al. | β | 2021 | β |
| Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids. | Marsee A et al. | β | 2021 | β |
| Cancer Cell Invasion of Mammary Organoids with Basal-In Phenotype. | Parigoris E et al. | β | 2021 | β |
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| Culture and differentiation of rabbit intestinal organoids and organoid-derived cell monolayers. | Kardia E et al. | β | 2021 | β |
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| Editorial. | Machado Fernandes H | β | 2021 | β |
| Establishment of Colorectal Cancer Organoids in Microfluidic-Based System. | Pinho D et al. | β | 2021 | β |
| Establishment of the vertebrate body plan: Rethinking gastrulation through stem cell models of early embryogenesis. | Steventon B et al. | β | 2021 | β |
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| Factors to consider when interrogating 3D culture models with plate readers or automated microscopes. | Riss T et al. | β | 2021 | β |
| Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development. | Zilova L et al. | β | 2021 | β |
| Future Match Making: When Pediatric Oncology Meets Organoid Technology. | Barbet V et al. | β | 2021 | β |
| Heart organoids and tissue models for modeling development and disease. | Miyamoto M et al. | β | 2021 | β |
| Heterocellular spheroids of the neurovascular blood-brain barrier as a platform for personalized nanoneuromedicine. | Kumarasamy M et al. | β | 2021 | β |
| Historical evolution of spheroids and organoids, and possibilities of use in life sciences and medicine. | Sakalem ME et al. | β | 2021 | β |
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| Hydrogels: A potential platform for induced pluripotent stem cell culture and differentiation. | Poorna MR et al. | β | 2021 | β |
| <i>In vitro</i> Models of the Small Intestine for Studying Intestinal Diseases. | Jung SM et al. | β | 2021 | β |
| Induction of apically mistrafficked epiregulin disrupts epithelial polarity via aberrant EGFR signaling. | Singh B et al. | β | 2021 | β |
| Integrating Biomaterials and Genome Editing Approaches to Advance Biomedical Science. | Abdeen AA et al. | β | 2021 | β |
| Integrating High-Throughput Approaches and <i>in vitro</i> Human Trophoblast Models to Decipher Mechanisms Underlying Early Human Placenta Development. | Lee BK et al. | β | 2021 | β |
| Intestinal multicellular organoids to study colorectal cancer. | Idris M et al. | β | 2021 | β |
| Investigating receptor-mediated antibody transcytosis using blood-brain barrier organoid arrays. | Simonneau C et al. | β | 2021 | β |
| In vitro modelling of the physiological and diseased female reproductive system. | StejskalovΓ‘ A et al. | β | 2021 | β |
| Keloid disorder: Fibroblast differentiation and gene expression profile in fibrotic skin diseases. | Macarak EJ et al. | β | 2021 | β |
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| Mechanical Studies of the Third Dimension in Cancer: From 2D to 3D Model. | Paradiso F et al. | β | 2021 | β |
| Mechanisms of radiation-induced endothelium damage: Emerging models and technologies. | Wijerathne H et al. | β | 2021 | β |
| Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism. | Elia I et al. | β | 2021 | β |
| Microengineered systems with iPSC-derived cardiac and hepatic cells to evaluate drug adverse effects. | Dame K et al. | β | 2021 | β |
| Modeling Intestinal Stem Cell Function with Organoids. | Takahashi T et al. | β | 2021 | β |
| Modeling mammalian trunk development in a dish. | Veenvliet JV et al. | β | 2021 | β |
| Modeling pancreatic pathophysiology using genome editing of adult stem cell-derived and induced pluripotent stem cell (iPSC)-derived organoids. | Hirshorn ST et al. | β | 2021 | β |
| Modelling Human Physiology on-Chip: Historical Perspectives and Future Directions. | Pun S et al. | β | 2021 | β |
| New Insights into the Clinical Implications of Yes-Associated Protein in Lung Cancer: Roles in Drug Resistance, Tumor Immunity, Autophagy, and Organoid Development. | Yoo G et al. | β | 2021 | β |
| Nontraditional systems in aging research: an update. | MikuΕa-Pietrasik J et al. | β | 2021 | β |
| Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs. | Brighi C et al. | β | 2021 | β |
| Organoid and Spheroid Tumor Models: Techniques and Applications. | Gunti S et al. | β | 2021 | β |
| Organoids as tools to investigate the molecular mechanisms of male infertility and its treatments. | Kanbar M et al. | β | 2021 | β |
| Organoids in cancer research: a review for pathologist-scientists. | Wood LD et al. | β | 2021 | β |
| Organoids to model liver disease. | Nuciforo S et al. | β | 2021 | β |
| Organotypic-liver slide culture systems to explore the role of extracellular vesicles in pancreatic cancer metastatic behavior and guide new therapeutic approaches. | Supadmanaba IGP et al. | β | 2021 | β |
| Overcoming TRAIL-resistance by sensitizing prostate cancer 3D spheroids with taxanes. | Grayson KA et al. | β | 2021 | β |
| Overview and Comparison of Intestinal Organotypic Models, Intestinal Cells, and Intestinal Explants Used for Toxicity Studies. | Maresca M et al. | β | 2021 | β |
| Phenotypic screening system using three-dimensional (3D) culture models for natural product screening. | Suenaga H et al. | β | 2021 | β |
| Post-Translational Regulations of Foxp3 in Treg Cells and Their Therapeutic Applications. | Dong Y et al. | β | 2021 | β |
| Predictable fabrication of pre-made alginate hydrogel microtubes for stem cell aggregation using needle-in-needle devices. | Jorgensen M et al. | β | 2021 | β |
| Prognostic Biomarkers in Uveal Melanoma: The Status Quo, Recent Advances and Future Directions. | Lamas NJ et al. | β | 2021 | β |
| Raman Imaging and Fluorescence Lifetime Imaging Microscopy for Diagnosis of Cancer State and Metabolic Monitoring. | Becker L et al. | β | 2021 | β |
| Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models. | Huang Y et al. | β | 2021 | β |
| Rethinking organoid technology through bioengineering. | Garreta E et al. | β | 2021 | β |
| Review of studies of severe acute respiratory syndrome related coronavirus-2 pathogenesis in human organoid models. | Egilmezer E et al. | β | 2021 | β |
| Somatic cell-derived organoids as prototypes of human epithelial tissues and diseases. | Fujii M et al. | β | 2021 | β |
| Specific substrates composed of collagen and fibronectin support the formation of epithelial cell sheets by MDCK cells lacking Ξ±-catenin or classical cadherins. | Suzuki ST et al. | β | 2021 | β |
| Spheroids and organoids as humanized 3D scaffold-free engineered tissues for SARS-CoV-2 viral infection and drug screening. | Kronemberger GS et al. | β | 2021 | β |
| Spinal Cord Neuronal Network Formation in a 3D Printed Reinforced Matrix-A Model System to Study Disease Mechanisms. | Fischhaber N et al. | β | 2021 | β |
| Synthetic living machines: A new window on life. | Ebrahimkhani MR et al. | β | 2021 | β |
| TeamTree analysis: A new approach to evaluate scientific production. | Pfrieger FW | β | 2021 | β |
| The anti-tumor effects of imidazolium salts on oral squamous cell carcinoma. | de Campos PS et al. | β | 2021 | β |
| The Application of the Tissue Microarray (TMA) Technology to Analyze Cerebral Organoids. | Biunno I et al. | β | 2021 | β |
| The Art of Engineering Biomimetic Cellular Microenvironments. | Bretherton RC et al. | β | 2021 | β |
| The epithelial-mesenchymal transition and the cytoskeleton in bioengineered systems. | Leggett SE et al. | β | 2021 | β |
| The Potential of Induced Pluripotent Stem Cells to Treat and Model Alzheimer's Disease. | Schulz JM | β | 2021 | β |
| The Potential of Pancreatic Organoids for Diabetes Research and Therapy. | Bittenglova K et al. | β | 2021 | β |
| Three-Dimensional Cell Cultures as a Research Platform in Lung Diseases and COVID-19. | da Silva da Costa FA et al. | β | 2021 | β |
| Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease. | Marconi GD et al. | β | 2021 | β |
| Ultra-High-Resolution 3D Optical Coherence Tomography Reveals Inner Structures of Human Placenta-Derived Trophoblast Organoids. | Deloria AJ et al. | β | 2021 | β |
| Use of Transparent Liquid Marble: Microbioreactor to Culture Cardiospheres. | Aalders J et al. | β | 2021 | β |
| 3D approaches to model the tumor microenvironment of pancreatic cancer. | TomΓ‘s-Bort E et al. | β | 2020 | β |
| Adapting the 14-day rule for embryo research to encompass evolving technologies. | Williams K et al. | β | 2020 | β |
| Advanced biomedical applications based on emerging 3D cell culturing platforms. | Wang A et al. | β | 2020 | β |
| Advances in Engineering Human Tissue Models. | Moysidou CM et al. | β | 2020 | β |
| All roads lead to Rome: the many ways to pluripotency. | Pennarossa G et al. | β | 2020 | β |
| Biosensors for Studies on Adhesion-Mediated Cellular Responses to Their Microenvironment. | Saffioti NA et al. | β | 2020 | β |
| Brain organoids: Human 3D models to investigate neuronal circuits assembly, function and dysfunction. | Tambalo M et al. | β | 2020 | β |
| Cell swelling, softening and invasion in a three-dimensional breast cancer model. | Han YL et al. | β | 2020 | β |
| Comparison of two human organoid models of lung and intestinal inflammation reveals Toll-like receptor signalling activation and monocyte recruitment. | Jose SS et al. | β | 2020 | β |
| Diabetes through a 3D lens: organoid models. | Tsakmaki A et al. | β | 2020 | β |
| Engineered tissues and strategies to overcome challenges in drug development. | Khalil AS et al. | β | 2020 | β |
| Exploiting CRISPR Cas9 in Three-Dimensional Stem Cell Cultures to Model Disease. | Gopal S et al. | β | 2020 | β |
| Generation of Mosaic Mammary Organoids by Differential Trypsinization. | Rubio S et al. | β | 2020 | β |
| Generation of small intestinal organoids for experimental intestinal physiology. | Capeling M et al. | β | 2020 | β |
| Human ileal organoid model recapitulates clinical incidence of diarrhea associated with small molecule drugs. | Belair DG et al. | β | 2020 | β |
| Human organoids: model systems for human biology and medicine. | Kim J et al. | β | 2020 | β |
| Immune Organs and Immune Cells on a Chip: An Overview of Biomedical Applications. | Morsink MAJ et al. | β | 2020 | β |
| Intestinal organoids for Cystic Fibrosis research. | de Poel E et al. | β | 2020 | β |
| iPSC-Derived Liver Organoids: A Journey from Drug Screening, to Disease Modeling, Arriving to Regenerative Medicine. | Olgasi C et al. | β | 2020 | β |
| Mammary Organoids and 3D Cell Cultures: Old Dogs with New Tricks. | Sumbal J et al. | β | 2020 | β |
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| Microphysiological Modeling of the Human Endometrium. | Campo H et al. | β | 2020 | β |
| Mimicking tumor hypoxia and tumor-immune interactions employing three-dimensional in vitro models. | Bhattacharya S et al. | β | 2020 | β |
| Modeling Alzheimer's disease with iPSC-derived brain cells. | Penney J et al. | β | 2020 | β |
| Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids. | Pan FC et al. | β | 2020 | β |
| Modeling the cornea in 3-dimensions: Current and future perspectives. | McKay TB et al. | β | 2020 | β |
| Modelling Pancreatic Neuroendocrine Cancer: From Bench Side to Clinic. | Ney A et al. | β | 2020 | β |
| Mouse pancreatic ductal organoid culture as a relevant model to study exocrine pancreatic ion secretion. | MolnΓ‘r R et al. | β | 2020 | β |
| Optimal, Large-Scale Propagation of Mouse Mammary Tumor Organoids. | Wrenn ED et al. | β | 2020 | β |
| Optimization of mouse embryonic stem cell culture for organoid and chimeric mice production | Martin-Lemaitre C et al. | β | 2020 | β |
| Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages. | Rosenbluth JM et al. | β | 2020 | β |
| Organoid models for mammary gland dynamics and breast cancer. | Srivastava V et al. | β | 2020 | β |
| Organoid Models of Colorectal Pathology: Do They Hold the Key to Personalized Medicine? A Systematic Review. | DeHaan RK et al. | β | 2020 | β |
| Pancreatic Ductal Adenocarcinoma (PDAC) Organoids: The Shining Light at the End of the Tunnel for Drug Response Prediction and Personalized Medicine. | Frappart PO et al. | β | 2020 | β |
| Patient-Derived Tumor Organoids for Drug Repositioning in Cancer Care: A Promising Approach in the Era of Tailored Treatment. | Vivarelli S et al. | β | 2020 | β |
| Production and characterization of avian crypt-villus enteroids and the effect of chemicals. | Acharya M et al. | β | 2020 | β |
| Progress in human liver organoids. | Sun L et al. | β | 2020 | β |
| Regulation of Collective Metastasis by Nanolumenal Signaling. | Wrenn ED et al. | β | 2020 | β |
| Regulation of epithelial-mesenchymal transition and organoid morphogenesis by a novel TGFΞ²-TCF7L2 isoform-specific signaling pathway. | Karve K et al. | β | 2020 | β |
| Repair and regeneration of small intestine: A review of current engineering approaches. | Qi D et al. | β | 2020 | β |
| Role of <i>NDE1</i> in the Development and Evolution of the Gyrified Cortex. | Soto-Perez J et al. | β | 2020 | β |
| Ruffles and spikes: Control of tight junction morphology and permeability by claudins. | Lynn KS et al. | β | 2020 | β |
| Sebaceous gland: Milestones of 30-year modelling research dedicated to the "brain of the skin". | Zouboulis CC et al. | β | 2020 | β |
| Self-Organized Liver Microtissue on a Bio-Functional Surface: The Role of Human Adipose-Derived Stromal Cells in Hepatic Function. | Hong S et al. | β | 2020 | β |
| Simulating the human colorectal cancer microenvironment in 3D tumor-stroma co-cultures in vitro and in vivo. | Devarasetty M et al. | β | 2020 | β |
| Spheres of Influence: Insights into <i>Salmonella</i> Pathogenesis from Intestinal Organoids. | Verma S et al. | β | 2020 | β |
| Spherical microwell arrays for studying single cells and microtissues in 3D confinement. | Huang CK et al. | β | 2020 | β |
| The endothelium, a key actor in organ development and hPSC-derived organoid vascularization. | Vargas-Valderrama A et al. | β | 2020 | β |
| The not-so-sweet side of sugar: Influence of the microenvironment on the processes that unleash cancer. | Mboge MY et al. | β | 2020 | β |
| Three dimensional engineered models to study hypoxia biology in breast cancer. | Aggarwal V et al. | β | 2020 | β |
| Three-Dimensional Human Cell Culture Models to Study the Pathophysiology of the Anterior Eye. | GarcΓa-Posadas L et al. | β | 2020 | β |
| Three dimensional in vitro models of cancer: Bioprinting multilineage glioblastoma models. | Hermida MA et al. | β | 2020 | β |
| Tracking cells in epithelial acini by light sheet microscopy reveals proximity effects in breast cancer initiation. | Alladin A et al. | β | 2020 | β |
| 3D Cardiac Cell Culture: A Critical Review of Current Technologies and Applications. | Zuppinger C | β | 2019 | β |
| 3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis. | Booij TH et al. | β | 2019 | β |
| 3D Cell Culture Models of Epithelial Tissues. | Zhang K et al. | β | 2019 | β |
| 3D culture models for studying branching morphogenesis in the mammary gland and mammalian lung. | Nerger BA et al. | β | 2019 | β |
| 3D models in the new era of immune oncology: focus on T cells, CAF and ECM. | Di Modugno F et al. | β | 2019 | β |
| All models are wrong, but some organoids may be useful. | Mead BE et al. | β | 2019 | β |
| A Microfluidic Platform Based on Robust Gas and Liquid Exchange for Long-term Culturing of Explanted Tissues. | Ota N et al. | β | 2019 | β |
| Anakoinosis: Correcting Aberrant Homeostasis of Cancer Tissue-Going Beyond Apoptosis Induction. | Heudobler D et al. | β | 2019 | β |
| Apathetic pathogens. | HΓ€fner S | β | 2019 | β |
| Application of Cancer Organoid Model for Drug Screening and Personalized Therapy. | Kondo J et al. | β | 2019 | β |
| Application of porcine gastrointestinal organoid units as a potential in vitro tool for drug discovery and development. | Olayanju A et al. | β | 2019 | β |
| Application of the D492 Cell Lines to Explore Breast Morphogenesis, EMT and Cancer Progression in 3D Culture. | Briem E et al. | β | 2019 | β |
| Approaching two decades of cystic fibrosis research in Qatar: a historical perspective and future directions. | Hammoudeh S et al. | β | 2019 | β |
| A reproducible scaffold-free 3D organoid model to study neoplastic progression in breast cancer. | Djomehri SI et al. | β | 2019 | β |
| Biomaterials: Been There, Done That, and Evolving into the Future. | Ratner BD | β | 2019 | β |
| Cancer modeling meets human organoid technology. | Tuveson D et al. | β | 2019 | β |
| Characterization of organoid cultured human breast cancer. | Goldhammer N et al. | β | 2019 | β |
| Concepts toward directing human astroplasticity to promote neuroregeneration. | Patel R et al. | β | 2019 | β |
| Development of Collagen-Based 3D Matrix for Gastrointestinal Tract-Derived Organoid Culture. | Jee JH et al. | β | 2019 | β |
| Emerging approaches to study cell-cell interactions in tumor microenvironment. | Nishida-Aoki N et al. | β | 2019 | β |
| Engineered materials for organoid systems. | Kratochvil MJ et al. | β | 2019 | β |
| From single cells to tissue self-organization. | Xavier da Silveira Dos Santos A et al. | β | 2019 | β |
| Generating Embryonic Salivary Gland Organoids. | Hosseini ZF et al. | β | 2019 | β |
| Generation of Organotypic Multicellular Spheres by Magnetic Levitation: Model for the Study of Human Hematopoietic Stem Cells Microenvironment. | MejΓa-Cruz CC et al. | β | 2019 | β |
| Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer. | Wadosky KM et al. | β | 2019 | β |
| Handling and Assessment of Human Primary Prostate Organoid Culture. | McCray T et al. | β | 2019 | β |
| Harnessing Human Microphysiology Systems as Key Experimental Models for Quantitative Systems Pharmacology. | Taylor DL et al. | β | 2019 | β |
| Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D cultures. | Schumacher D et al. | β | 2019 | β |
| Human adipose stromal-vascular fraction self-organizes to form vascularized adipose tissue in 3D cultures. | Muller S et al. | β | 2019 | β |
| Human organoids: a new dimension in cell biology. | Lehmann R et al. | β | 2019 | β |
| In Vitro 3D Cultures to Reproduce the Bone Marrow Niche. | Ham J et al. | β | 2019 | β |
| iRGD-guided tamoxifen polymersomes inhibit estrogen receptor transcriptional activity and decrease the number of breast cancer cells with self-renewing capacity. | Diaz Bessone MI et al. | β | 2019 | β |
| Laminin promotes differentiation of rat embryonic stem cells into cardiomyocytes by activating the integrin/FAK/PI3K p85 pathway. | Wang D et al. | β | 2019 | β |
| Liver organoids: from basic research to therapeutic applications. | Prior N et al. | β | 2019 | β |
| Mesenchymal stem cell 3D encapsulation technologies for biomimetic microenvironment in tissue regeneration. | Kim H et al. | β | 2019 | β |
| Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments. | Blache U et al. | β | 2019 | β |
| Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential. | Karolak A et al. | β | 2019 | β |
| Organoids are promising tools for species-specific in vitro toxicological studies. | Augustyniak J et al. | β | 2019 | β |
| Organoids by design. | Takebe T et al. | β | 2019 | β |
| Organoids for Drug Discovery and Personalized Medicine. | Takahashi T | β | 2019 | β |
| Organoids Increase the Predictive Value of <i>in vitro</i> Cancer Chemoprevention Studies for <i>in vivo</i> Outcome. | Njoroge RN et al. | β | 2019 | β |
| Organoid technology in cancer precision medicine. | Xia X et al. | β | 2019 | β |
| Preclinical Organotypic Models for the Assessment of Novel Cancer Therapeutics and Treatment. | Ward C et al. | β | 2019 | β |
| Quantitative Imaging of Morphometric and Metabolic Signatures Reveals Heterogeneity in Drug Response of Three-Dimensional Mammary Tumor Spheroids. | Ramanujan VK | β | 2019 | β |
| Recent progress in organoid culture to model intestinal epithelial barrier functions. | Nakamura T | β | 2019 | β |
| Simple In-House Fabrication of Microwells for Generating Uniform Hepatic Multicellular Cancer Aggregates and Discovering Novel Therapeutics. | Chiu CY et al. | β | 2019 | β |
| The migration and fusion events related to ROCK activity strongly influence the morphology of chicken embryo intestinal organoids. | Pierzchalska M et al. | β | 2019 | β |
| The promises and challenges of patient-derived tumor organoids in drug development and precision oncology. | Granat LM et al. | β | 2019 | β |
| Three-dimensional testicular organoids as novel <i>in vitro</i> models of testicular biology and toxicology. | Sakib S et al. | β | 2019 | β |
| Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. | Samocha A et al. | β | 2019 | β |
| Use of a Super-hydrophobic Microbioreactor to Generate and Boost Pancreatic Mini-organoids. | Brevini TAL et al. | β | 2019 | β |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | β | 2019 | β |
| Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer. | Smith R et al. | β | 2019 | β |
| Advancing Intestinal Organoid Technology Toward RegenerativeΒ Medicine. | Nakamura T et al. | β | 2018 | β |
| A new approach to assess drug sensitivity in cells for novel drug discovery. | Mazzarella L et al. | β | 2018 | β |
| Biobanking Organoids or Ground-State Stem Cells? | Xian W et al. | β | 2018 | β |
| Deconstructing and reconstructing the mouse and human early embryo. | Shahbazi MN et al. | β | 2018 | β |
| Differential Expression of Cholinergic System Components in Human Induced Pluripotent Stem Cells, Bone Marrow-Derived Multipotent Stromal Cells, and Induced Pluripotent Stem Cell-Derived Multipotent Stromal Cells. | Weist R et al. | β | 2018 | β |
| FGF2-dependent mesenchyme and laminin-111 are niche factors in salivary gland organoids. | Hosseini ZF et al. | β | 2018 | β |
| Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells. | Hoang P et al. | β | 2018 | β |
| Ground-State Stem Cells: A Novel Approach for Adult Stem Cell Research. | Xian W et al. | β | 2018 | β |
| Human-specific approaches to brain research for the 21st century: a South American perspective. | Triunfol M et al. | β | 2018 | β |
| In vivo therapeutic applications of cell spheroids. | Ong CS et al. | β | 2018 | β |
| Macromolecule-Network Electrostatics Controlling Delivery of the Biotherapeutic Cell Modulator TIMP-2. | Yamada Y et al. | β | 2018 | β |
| Microsensor systems for cell metabolism - from 2D culture to organ-on-chip. | Kieninger J et al. | β | 2018 | β |
| Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age. | Barrila J et al. | β | 2018 | β |
| Modeling Tissue Polarity in Context. | Tharp KM et al. | β | 2018 | β |
| Opportunities for organoids as new models of aging. | Hu JL et al. | β | 2018 | β |
| Optimized Clump Culture Methods for Adult Human Multipotent Neural Cells. | Yeon JY et al. | β | 2018 | β |
| Organoids for Modeling Genetic Diseases. | Perez-Lanzon M et al. | β | 2018 | β |
| Organoids Provide an Important Window on Inflammation in Cancer. | Baker K | β | 2018 | β |
| Progress and potential in organoid research. | Rossi G et al. | β | 2018 | β |
| Successful creation of pancreatic cancer organoids by means of EUS-guided fine-needle biopsy sampling for personalized cancer treatment. | Tiriac H et al. | β | 2018 | β |
| The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices. | Senthebane DA et al. | β | 2018 | β |
| Three-dimensional cell culture: from evolution to revolution. | Alhaque S et al. | β | 2018 | β |
| Three-Dimensional <i>in Vitro</i> Cell Culture Models in Drug Discovery and Drug Repositioning. | Langhans SA | β | 2018 | β |
| Visualizing collagen proteolysis by peptide hybridization: From 3D cell culture to in vivo imaging. | Bennink LL et al. | β | 2018 | β |
| A Genome-wide Analysis of Human Pluripotent Stem Cell-Derived Endothelial Cells in 2D or 3D Culture. | Zhang J et al. | β | 2017 | β |
| A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features. | Sgodda M et al. | β | 2017 | β |
| A tunable refractive index matching medium for live imaging cells, tissues and model organisms. | Boothe T et al. | β | 2017 | β |
| Convergence of microengineering and cellular self-organization towards functional tissue manufacturing. | Laurent J et al. | β | 2017 | β |
| Converging biofabrication and organoid technologies: the next frontier in hepatic and intestinal tissue engineering? | Schneeberger K et al. | β | 2017 | β |
| Deciphering Cell Intrinsic Properties: A Key Issue for Robust Organoid Production. | Picollet-D'hahan N et al. | β | 2017 | β |
| Dissecting the stem cell niche with organoid models: an engineering-based approach. | Murrow LM et al. | β | 2017 | β |
| Goodbye flat biology - time for the 3rd and the 4th dimensions. | Bissell MJ | β | 2017 | β |
| Intersections of lung progenitor cells, lung disease and lung cancer. | Kim CF | β | 2017 | β |
| Multicellular tumor invasion and plasticity in biomimetic materials. | Leggett SE et al. | β | 2017 | β |
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